4‐(2‐Hydroxyethyl)‐1‐piperazine ethane sulfonic acid repositioning: Amyloid disaggregating agent and its <scp>sustained‐release</scp> system
نویسندگان
چکیده
Abstract Here, we report the results of experiments regarding chemical repositioning 4‐(2‐hydroxyethyl)‐1‐piperazine ethane sulfonic acid ( HEPES ), a representative buffering agent. In this work, confirmed that could disaggregate amyloid plaques, hallmark Alzheimer's disease, and verified its sustained‐release system (release for up to 2 weeks) via hybridization with biocompatible polymer (Eudragit S100).
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ژورنال
عنوان ژورنال: Bulletin of The Korean Chemical Society
سال: 2021
ISSN: ['0253-2964', '1229-5949']
DOI: https://doi.org/10.1002/bkcs.12433